Ms. Pat started doing comedy after being encouraged by her caseworker. She did her first stand-up in Atlanta in 2002. Her career as a comic elevated to the next stage in 2006, after she moved to Indianapolis, where she improved her comedic skills at Morty’s, a well-known comic store.

In 2015, she participated in the ninth season of NBC’s Last Comic Standing.

Ms. Pat has appeared on popular shows and podcasts hosted by Kevin Hart, Marc Maron, Joe Rogan, Eddie Ifft, Bert Kreischer, Joey “CoCo” Diaz, Bobby Lee and Ari Shaffir. She is also a frequent guest talent on the comedy program titled The Bob & Tom Show.

In 2017, she released her first stand-up album, Rabbit. In 2018, she appeared in Netflix’s stand-up series The Degenerates. On February 8, 2022, Netflix released her hour-long comedy special, “Ms. Pat: Y’all Wanna Hear Something Crazy?”